There is an old saying in medicine that “the cure may be worse than the disease.” The phrase can be applied to vaccines. In the current paper the concern is raised that the RNA based COVID vaccines have the potential to cause more disease than the epidemic of COVID-19. This paper focuses on a novel potential adverse event mechanism causing prion disease which could be even more common and debilitating than the viral infection the vaccine is designed to prevent. While this paper focuses on one potential adverse event there are multiple other potential fatal adverse events as discussed below.
Vaccines have been found to cause a host of chronic, late developing adverse events. Some adverse events like type 1 diabetes may not occur until 3-4 years after a vaccine is administered . In the example of type 1 diabetes the frequency of cases of adverse events may surpass the frequency of cases of severe infectious disease the vaccine was designed to prevent. Given that type 1 diabetes is only one of many immune mediated diseases potentially caused by vaccines, chronic late occurring adverse events are a serious public health issue.
What are human prion diseases?
Creutzfeldt-Jakob (KROITS-felt YAH-kobe) disease (CJD) is a degenerative brain disorder that leads to dementia and, ultimately, death. Creutzfeldt-Jakob disease symptoms can be similar to those of other dementia-like brain disorders, such as Alzheimer's disease. But Creutzfeldt-Jakob disease usually progresses much more rapidly.
CJD captured public attention in the 1990s when some people in the United Kingdom developed a form of the disease — variant CJD (vCJD) — after eating meat from diseased cattle.
The prion hypothesis explained why the mysterious infectious agent is resistant to ultraviolet radiation, which breaks down nucleic acids, but is susceptible to substances that disrupt proteins.
Definition UVR - UV radiation: Ultraviolet radiation. Invisible rays that are part of the energy that comes from the sun, can burn the skin, and cause skin cancer. UV radiation is …
Radiation in the part of the electromagnetic spectrum where wavelengths are just shorter than those of ordinary, visible violet light but longer than those of x-rays.
Prion diseases are a group of neurodegenerative diseases caused by prions, which are “proteinaceous infectious particles.” For some background, first see this introduction to prions. Prion diseases are caused by misfolded forms of the prion protein, also known as PrP. These diseases affect a lot of different mammals in addition to humans – for instance, there is scrapie in sheep, mad cow disease in cows, and chronic wasting disease in deer.
Even though prion diseases do come in slightly different forms, they have a whole lot in common. In each disease, the prion protein (PrP) folds up the wrong way, becoming a prion, and then causes other PrP molecules to do the same. Prions can then spread “silently” across a person’s brain for years without causing any symptoms. Eventually prions start to kill neurons, and once symptoms strike, the person has a very rapid cognitive decline. Most prion diseases are fatal within a few months, though some can last a few years [Pocchiari 2004].
Prion diseases, also known as transmissible spongiform encephalopathies or TSEs, are a group of rare, fatal brain diseases that affect animals and humans. They are caused by an infectious agent known as a prion, which is derived from a misfolded version of a normal host protein known as prion protein. Prion diseases include bovine spongiform encephalopathy (BSE or "mad cow" disease) in cattle, Creutzfeldt-Jakob disease (CJD) and variant CJD in humans, scrapie in sheep, and chronic wasting disease (CWD) in deer, elk, moose and reindeer.
Prion diseases are a significant public health concern and have been known to spread from animals to people and, in the case of variant Creutzfeldt-Jakob disease, from human to human through blood. Prion diseases in people are difficult to diagnose and, when they are diagnosed, there are no effective treatments available. As a result, they are inevitably fatal.
NIAID scientists are examining how prion diseases develop and spread between people and animals, how they can be diagnosed, and how they can be treated. NIAID conducts prion disease research at its Rocky Mountain Laboratories in Hamilton, Montana, and also funds prion disease research in university labs. NIAID collaborations with other NIH groups studying aging disorders and neurological diseases also are important.