Thursday, January 17, 2019

Mengla: Ebola-like virus found in China

Mengla: the Ebola-like virus recently found in China

Image result for fruit bats in Yunnan Province, China

Scientists from China and Singapore recently reported the discovery of an Ebola-like virus in the liver of fruit bats in Yunnan Province, China. The Mengla virus, named for the county it was discovered in, shares many of the characteristics of the deadly Ebola virus and has the potential to infect humans.
The Mengla virus belongs to the small but deadly family of filoviruses, which includes Ebolavirus, Marburgvirus and Cuevavirus. These viruses are known to cause severe haemorrhagic fever in humans, apes and monkeys, but there is no suggestion that the Mengla virus has been transmitted to humans.
Scientists in China had previously found evidence, in the form of antibodies, of several filoviruses in Rousettus and Eonycteris bats and provided evidence that they were filoviruses – initially labelled as “unclassified”. These same scientists then extended their investigation to explore the genetics of a virus collected from Rousettus bats from Mengla County.
Having genetically sequenced the Mengla virus, they discovered that it has 32-54% genetic similarity with known filoviruses and sits somewhere between the Ebola and Marburg viruses on the evolutionary tree. However, the Mengla virus is different enough to warrant its own genus. The new genus has been named Dianlovirus, and it sits in the filovirus group.
The genome of the Mengla virus indicated that it carries a protein on its surface that is similar to other filoviruses that can infect mammals. They found that the Mengla virus uses the same NPC1 receptor that other filoviruses use to enter and infect cells, which suggests that it could infect humans, monkeys, dogs, hamsters and bats. The virus has the potential to either infect humans directly or by first infecting other animals. However, further studies are needed to demonstrate this potential.
The scientists also compared this novel virus genome to Ebola and Marburg viruses and identified incredible similarity in how the genome is organised. Although scientists have not yet sequenced the entire genome of the virus, there is convincing evidence that the Mengla virus can jump to humans through urbanisation and deforestation and the close interaction between humans and animals that this encourages.
Filoviruses, like Ebola, are deadly. AHMED JALLANZO/EPA

Bat-borne viruses

Among all wildlife species, bats represent the second most diverse group of mammals and harbour more than 65 human pathogens. Bats are particularly well known as carriers of filoviruses.
In 2018, a new Ebola virus was discovered in free-tailed bats in Sierra Leone. The characteristics of the newly named Bombali virus is similar to previously discovered Ebola viruses, but the risk to humans is higher because free-tailed bats are known to roost in people’s homes. And at least one species of bat in Africa has been found to host the Marburg virus, indicating the potential role of bats in the spread of filoviruses due to close residential dwelling between human and bats.
Recent discoveries of novel viruses in bats and their potential in spreading diseases has threatened global public health, especially in Africa due to the consumption of bat “bushmeat”. Moreover, hunting bats for both food and money has put humans at significantly higher risk of zoonotic (from animal to human) spillover of viruses.
The recent filovirus outbreaks have challenged health officials in Africa in containing the disease to borders and hindering the spread to Europe. Now identification of this new Mengla virus explains the genetic diversity of filoviruses beyond Africa. It is a warning that we need to continuously monitor and swiftly respond to emergency situations of possible future disease emergence.
Different novel viruses have been reported in bats in the last decade, which underlines the need to continuously study the diversity of emerging viruses and their potential to cause infection in human and other animals. These insights will help to plan future mitigation strategies, including control and treatments as well as long-term management of disease risks.

Wednesday, January 9, 2019

Senescence - cells that make us age faster and how to get rid of them

Natural Compounds that Remove Aging Cells

October 2016
By Sherrie Oppenheimer
Scientists have recently been focused on a new class of drugs1 aimed at eliminating aging cells from our bodies.
The goal of these experimental drugs is to eliminate poorly functioning, senile cells that clog our bodies and induce a range of degenerative illnesses.
This form of biological housekeeping frees the body from sluggish, slowly dying cells and allows it to function better with newer, healthier cells. This rejuvenation occurs naturally in our youth but declines with age.
Researchers have discovered that two natural compounds target and discard aging cells from the body, making way for the production of new, healthy cells.

Targeting Cellular Senescence

Natural compounds that remove aging cells 
Cellular senescence is an underlying contributor to accelerated aging and disease.2
Aging, or “senile,” cells stop dividing to produce new cells and lose their ability to die off, which causes them to build up in the body. These accumulated cells pour out harmful, pro-inflammatory chemicals and other signaling molecules that contribute to aging and increase the risk of most age-related diseases—including cancer.3-5
Ridding the body of these aging cells to make way for fresh new cells is an important target for slowing aging and reducing disease risk.6 This is the goal of pharmaceutical researchers as they develop new drugs to purge senile cells from aging bodies.
But senescence is a double-edged sword. While it is harmful in healthy cells, senescence is desirable in tumor cells because it halts their out-of-control replication. By definition, cancer cells have become “immortal,” and continue to replicate without forming useful structures. By “turning back on” the senescence process, cancer cells can be made “mortal” again and eventually die off. In fact, deliberately triggering senescence in malignant cells represents a new approach to fighting cancer.6
The idea that we can use natural substances to selectively target cellular senescence has opened a promising new door in the fight against cancer and aging.6
Studies have used drugs and synthetic biological products capable of clearing away accumulated aging cells in aging tissues. In animals, these compounds have produced dramatic results, such as delaying the onset of aging, slowing existing age-related changes, and even extending lifespans.7-9 But in their current state of development, these drugs and other synthetic products are impractical, dangerous, or both, making them entirely unsuitable for use in humans to prevent either aging or cancer.
Researchers have found that two natural compounds, when combined, successfully remove aging cells from the body without harmful side effects.

Tocotrienols + Quercetin

Tocotrienols, the less well-known members of the vitamin E family, are emerging as the ideal senolyticnutrient. Studies show that tocotrienols have dual and complementary actions:
  • In cancer cells, tocotrienols can stimulate cellular senescence, shutting down their malignant potential.6
  • In healthy tissue, tocotrienols can slow aging changes, promote normal cell division and specialization, and prevent cells from reaching their damaging final aging state.10-14
Studies have shown the benefits of combining tocotrienols with quercetin, a flavonol found in many fruits and vegetables. Quercetin also has dual and complementary actions with regards to aging cells. Like tocotrienols, quercetin can induce senescence and promote cell death in numerous types of cancer cells.6,15And, like tocotrienols, quercetin has the opposite effect in healthy cells, delaying senescence in younger cells and rejuvenating older cells to rid them of their abnormal, age-promoting function.1,6
Together, these two nutrients sweep the body clear of aging cells, while promoting natural termination of cancer cells.
what you need to know

Tocotrienols Combat Aging and Cancer

  • The accumulation of non-replicating aging cells in healthy tissue promotes aging throughout the body.
  • At the same time, cancer cells lose the ability to grow old and stop replicating, leaving them free to multiply endlessly, invading and destroying tissue as they go.
  • Tocotrienols, members of the vitamin E family, have recently been shown to exert dualistic actions on healthy and malignant cells, stimulating natural growth and delaying senescence in otherwise healthy cells, but inducing senescence and stopping growth in malignant cells.
  • These properties make tocotrienols among the most promising senolytic compounds that are readily available.
  • Tocotrienols have also been shown to fight type II diabetes, and metabolic syndrome, while also delaying neurodegeneration.

Combined Anti-Aging Effects

Several studies have now been performed on the combination of tocotrienols and quercetin in slowing, delaying, or even reversing the consequences of senescence—particularly the excessive inflammatory signals that aging cells produce.16-18
A key reason why aging cells are so closely tied to aging and disease is because they pour out substances that generate inflammation throughout the body.3,19 In fact, aging cells are now recognized as an important source of the chronic inflammation that is known to produce age-related diseases.16
Growing evidence from animal models shows that the combination of tocotrienols plus quercetin sharply reduces blood levels of pro-inflammatory molecules.16 By suppressing these damaging factors, tocotrienols and quercetin reduce systemic inflammation in the body.17,18 Reducing inflammation has the beneficial effect of reducing the overall risk of aging and disease.
What are aging cells?
Cellular senescence is a natural process by which cells lose their ability to continue to divide. This process is essential for the prevention of cancer because it puts an upper limit on normal cell replications. It is also essential in tissue remodeling which occurs during development of embryos and during wound healing.9 In both of these special cases, rapid cell replication must be balanced by appropriate growth arrest so that normal structures form.
But aging cells remain alive, surviving in tissues without contributing much to the overall health of the organism over time.9 Worse, aging cells disrupt tissue structures and alter tissue function because of certain molecules that they secrete.7 Chief among these deleterious signaling molecules are mediators of inflammation (cytokines and other pro-inflammatory molecules).3,19
These inflammatory changes spread to other cells in the area, hastening their own decline into an aging state, and further accelerating the overall aging of the organism.3,19
Conversely, when cells lose their ability to age, they continue to grow far past their natural limits.54
Thus, gaining precise control over the process of cellular senescence would represent a huge breakthrough in our ability to slow aging (by preventing aging changes and/or clearing away aging cells), and in our capacity to fight cancer (by deliberately inducing aging changes in malignant cells to stop their growth).

New Approach to Fighting Cancer

As we’ve seen, cancer cells are essentially “immortal” in part because they have lost the ability to enter senescence, and hence, to stop their out-of-control replication. That means that deliberately inducing senescence in cancer cells is a potentially effective method of slowing or stopping a tumor from continuing to grow—or even from developing in the first place.
Mounting evidence has demonstrated that treating malignant cells with tocotrienols has several anti-tumor effects, including:
  • Inducing mitochondrial damage, which starves cancer cells of energy, and
  • Inducing apoptosis, the normal cell death program that cancer cells lose.20-24
What is so remarkable is that these cell-damaging effects are not seen in healthy, non-malignant cells, which means that tocotrienols selectively target cancer cells.21
In addition to helping prevent the growth and development of tumors, it appears that tocotrienols could also play a role in preventing them from spreading to other parts of the body. Studies of cultured cells show that tocotrienols are intimately involved in the regulation of tumor cell invasion and metastases, through their intricate control of sign-aling pathways used by those cells.25
One specific member of the tocotrienol family, gamma tocotrienol, has its own list of actions against cancer cells. These include blocking the formation of new blood vessels (angiogenesis) that is required to feed fast-growing tumors, thereby starving them of their nutrient and oxygen sources,26,27 and inhibiting the production of the inflammatory molecules that are associated with aging cells and that promote cancer growth.28
Tocotrienols are members of the vitamin E family of essential nutrients, naturally found in barley, wheat germ, and certain types of grains and nuts.55 There are four tocotrienols, just as there are four tocopherols, which are the more familiar form of vitamin E, and are similarly labeled alpha, beta, gamma, and delta.55-57 Early research, however, focused almost exclusively on the tocopherol class, and not the tocotrienol class. In a review of all publications on vitamin E, only about 3% have examined the utility of tocotrienols.56
But tocotrienols are now recognized to be an important part of the spectrum of the eight different forms of vitamin E, particularly for their anti-inflammatory, cholesterol-lowering, and radiation-protecting properties.56,57
Now, tocotrienols are being shown to have a still more fundamental role in human health and aging, through their abilities to modulate cellular senescence. This finding may in fact represent tocotrienols’ most fundamental natural purpose. One recent study by botanists shows that tocotrienols in the outer layer of seeds reduce metabolic activity in the seed during stressful external conditions.58 Those conditions resemble the accumulated stress seen in aging, and, if not prevented in the developing plant embryo, lead to death of the seed.
Thus, tocotrienols appear to be one of nature’s anti-aging compounds. We are now learning just how applicable their properties are in human aging as well.

Impressive Studies

impressive studies 
Laboratory and preclinical studies suggest that tocotrienols may combat senescence-related deterioration. One in vitro experiment showed that tocotrienols may reverse premature aging of muscle cells by enhancing their regenerative capacity.29 Another cell study found that tocotrienols reversed senescence-associated cell cycle arrest, reduced DNA damage, and restored telomerase activity in human connective tissue cells.30 Several other lab studies have revealed similarly intriguing findings.6,31 In aged mice, tocotrienols increased mitochondrial function in the brain,32 and reduced the age-related decline in T-cell function.33
The ability of tocotrienols to slow the growth of cancer cells—as well as enhance their ability to die off naturally—has led to impressive results in animal studies of cancer.
One study showed that in mice that had been injected with human colon cancer cells, those being fed tocotrienol-rich plant oil demonstrated a significant inhibition of tumor growth.34
But what makes tocotrienols particularly unique is that while they induce senescence in cancer cells, they prevent aging changes in healthy tissues. This ability to selectively target cancer cells while protecting healthy cells was clearly seen in a study utilizing high doses of radiation.
Radiation therapy is often used in the treatment of malignant tissues, with the aim of destroying cancer cells. Unfortunately, this has the obvious side effect of producing radiation damage in healthy tissue as well, which can lead to premature cell senescence, dysfunction, and death—particularly in tissues with normally rapid cell turnover, such as the intestine. It can also lead to potentially life-threatening side effects and considerable misery.
But something remarkable happened when mice were supplemented with tocotrienols (human equivalent dose of 1 gram) prior to whole-body radiation. Normal intestinal cells sharply increased their expression of life-preserving genes that prevent cell death by apoptosis. In other words, while tocotrienols are senescence-inducing in cancer cells, this experiment showed that tocotrienol supplementation prevented radiation-induced aging changes in healthy 
Several trials have shown benefits with daily doses of roughly 40400 mg of tocotrienols in relation to lipid metabolism,36-44 brain health,42 liver health,43,44 immune system function,45 and prevention of damage to DNA.46
Quercetin is a low-cost dietary supplement that has health-promoting properties in the heart, brain, and other systems.
Doses of 150 mg per day of quercetin have demonstrated benefits and might be a good maintenance dose.
For those who have not taken quercetin before, a prudent course might be to take around 500-800 mg per day of quercetin for three months to help purge accumulated senile cells and then stay with a maintenance dose of 150 mg each day thereafter.
For tocotrienols, use a palm-oil derived source and take around 150 mg per day for the first three months with a maintenance dose after that of about 100 mg each day thereafter.
As of the time of this article, the anti-senescence properties of these ingredients have only been demonstrated in cell studies and/or animal models. Research in humans is needed to establish an ideal dosage regimen for these ingredients to combat cellular senescence in humans.
Note: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking tocotrienols or high-dose quercetin.


Tocotrienols, the less well-known members of the vitamin E family, are of great interest to researchers. Recent studies show that tocotrienols have the ability to slow cellular aging in normal tissues, while reducing inflammation. At the same time, in what seems to be a remarkable fashion, tocotrienols may accelerate the destruction of cancer cells.
Tocotrienols, particularly in combination with quercetin, appear capable of removing many aging cells.
Tocotrienols have other anti-aging effects that are proving beneficial in our fight against diabetes, metabolic syndrome, and neuro-degeneration.42,47-53
If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.

LOXISM - jewish Hate for White Christians

Jews View All European Goys as Christians, And I’ll Tell You Why

The Right Stuff
October 18, 2016
In Week 55 of Fash The Nation, Jazzhands brought up that article Ethan Jacobs wrote (archived), in which he claimed in his analysis of the Alt-Right that, among other things, membership into the Alt-Right is reserved entirely for White Christian Men.
Unsurprisingly, Jazzhands spent some time unpacking this false assumption, and slinging mud at Ethan for being a low-agency Jew who generally didn’t do the research he claims (or implies) he did. He then concluded by theorizing that the left is simply trying to compartmentalize us so they can label us with an eye towards marginalizing and smearing.
Pictured: A (((freelance writer and political opinionist))).
However, interestingly enough, this isn’t actually as straightforward an issue as it seems. I know this, because I happen to work with some Jews, and I know their thought patterns and how they look at the world. Jews in general see all Anglo-Germanic white people as being Christian, no matter what they happen to personally believe in or profess to. So Ethan Jacobs is not wrong. He is just being a Jew.
But why, exactly, do Jews see white people in the West as just being Christian? Is it simply a generalization? Is it a smear tactic, as Jazzhands hypothesized? Is it misinformation? Base laziness? Or maybe it is just a lack of concern about the facts regarding the goyim? I will refrain from saying it is not any of those things, because they honestly are probably contributing factors.
There are actually two main reasons the Jews view all Anglo-Germanic whites as being Christians, and I will explain them both. It will shed some light on why Jews like Ethan Jacobs do and say the things they do. There is a rationale to it, and a purpose behind it. And unsurprisingly, it is not a nice one.
The first reason is a simple and profound one. Jews see us as a reflection of themselves. It should not be news to anyone that the way an individual views the world is impacted strongly by their own experiences and worldview. No one is capable of truly being completely objective, since everything we see and do is tainted by our own experiences, thoughts, and emotions. The entire purpose of the scientific method is to help us be objective, because being objective is not our default state.
As a result, we tend to see things from our own experiences in the things around us, and we see parts of ourselves in the people we know. This is simply the brain using what it already knows to process new information more efficiently, and it is an entirely natural and normal behavior.
This is relevant because on a very basic level, the Jews see the world differently than we do, because they are Jews. They ascribe some of their own characteristics to us as they observe us and try to understand us, the most important being the diaspora.
To the Jew, ideology, religion, blood, political affiliations, and even culture are all interchangeable. An atheistic militant Anarcho-Communist Jew with generations of pure Serbian blood on his father’s side and the thinnest of Jewish blood on his mother’s side is seen as no less of a Jew than a devout Orthodox Jew pacifist from New Jersey whose mother and father are both Jewish back a dozen generations. Strictly speaking, these two Jews have nothing in common whatsoever, except for the fact that they will see both of each other as being Jews and will behave and treat one another as if they were both Jews.
This is because, to the Jew, Jewishness is a divine state that transcends everything else. They track Jewish blood through the maternal line, not the paternal, which gives Jewish blood an infinite capacity to be diluted. So while Jews are a “race,” that race is itself open to being infinitely changed and altered, as long as the sequence in which it was changed follows down from mother to daughter. So strictly speaking, any two given Jews do not even have to be members of the same race by the standards of science to still be seen as blood Jews by the Jews themselves.
We see this in our own observations of Jews, and comment on it often as their ability to “shapeshift.” One moment they are a religion, in another moment they are a racial minority, and in yet another they are simply Yet Another H’wyte Person, whichever happens to be more convenient to them.
To us, this seems like an endless sequence of flip-flopping. To the Jew, they remain perfectly consistent, because what makes them Jews to them is not something confined to merely being a set of beliefs or even a specific type of blood. To be a Jew is to be Chosen, and it supersedes everything else.
That is the diaspora.
And they, correctly, assign this status to us as well.
It seems strange for us to think of it in such a way, because we don’t really consider ourselves a diaspora in the same way they do. We certainly lack, at least in the modern day, the brotherhood and camaraderie one might associate with such a thing. Whites do not put other whites first the same way Jews do. We might think of ourselves in a sense of Imperialistic spheres of political influence, or as a branching tree of genetic cousins, but we the collective white peoples have no conception of ourselves as a “white race,” for we are truthfully many races, nor do we see ourselves as a singular culture, but as many different cultures.
But what really is and what someone sees reality as being do not always match up, and just because we do not see ourselves as being part of a diaspora does not mean were are not still members of one.
Such is it with the Jews. To the Jew, the white man or woman of the West is indisputably Christian, no matter what they say or do to the contrary. A white liberal British man who sneers at the Church and speaks disdainfully of sky daddies and volcano gods is no less a Christian in their eyes than a rabidly atheistic Jewish professor in a Canadian university is Jewish. They see the aforementioned British Liberal as being profoundly Christian, fundamentally Christian. He is Christian from the far ends of his hair to the very tips of his toes. Whether Christians accept him or reject him and whether he accepts or rejects Christianity is irrelevant. It doesn’t matter. He lives in a culture that is profoundly and fundamentally Christian by their standards, he assumes morals and ethics that are grounded in Christian teachings and schools of thought instead of Judaic ones, and he is the heir to a venerable line of academic, philosophical, scientific, and legal institutions created by Christians for the express intent of furthering Christian civilization, just as they themselves are heir to a similar line of Rabbinical works that exist to fulfill a similar purpose.
What he professes to believe is irrelevant to them. Whether he has ever put his hands together in prayer or set foot in a church in his life is irrelevant to them. Even whether he wants to help his nation commit suicide or if he wishes to save it is, in this specific judgement, irrelevant to them.
Just as they view Jewishness as being a “special status” that transcends culture, philosophy, religion, and in many ways blood, and indeed informs all of those aforementioned things, so to do they see Christianity as a similar, rival special status which informs the actions and beliefs of every white European on the planet.
Jews have a conception of us which we ourselves once had but no longer possess, that being the idea of a “Cultural Christian.” In the postmodern world, the idea of a ‘Cultural Christian’ seems strange to us, because we see Christianity as a matter of belief or unbelief, but to the Jews, it is par for the course. All of their patterns of thought are informed through the lens of tribalism, so it only makes sense that they would view Christianity as a rival tribe similar in trait and form to their own.
And all of the missionary work and principled brown pastors in the world won’t change the fact that Jews see Christianity as being, first and foremost, profoundly White and intrinsically European.
In fact, it actually goes even further than this. Islam also functions as a diaspora, and even uses this form and status as a means of attack and conquest. Where Muslims cannot go ideologically, they spread racially, and where they cannot go as a race, they go as ideas, or in the more modern context, as accusations of oppression and colonialism. Islam cycles between being a race, a religion, a philosophy, a body politic, a culture, and a means of law, adopting as many of these traits as it can at any given moment in whatever combination most enables it to fly beneath the local radar.
Indeed, the modern day clash of culture and civilization could be accurately summarized as the Jewish, Muslim, and Christian diasporas being locked in a three-way war with one another for dominance over the face of the earth. Much of the agitation of the American establishment for war against Russia makes sense only when understood through the context that the Jewish diaspora, having co-opted America as a political engine, wish to use it to destroy Russia, a bastion of Christianity.
The problem we have is that although this is indeed a war of competing diasporas, we alone are under the impression that we are not a diaspora and that there is no war. We were, through the efforts of Cultural Marxism, convinced by the Jewish diaspora that we no longer have any sort of shared identity, and indeed retroactively never did. And they have now laid us open, or are attempting to lay us open, to being annihilated by Islam.
What is the most Jewish way to wage war you could imagine, dear reader? If I was pressed to come up with an answer, I would probably say “manipulate your enemies into killing each other.”
And that is exactly what they have done.
The second reason Jews like Ethan Jacobs conflate Europeans with Christians is much more straight-forward. Jews fear and hate Christians, and Jews fear and hate white people. As people are often wont to do, they will conflate and use interchangeably things that they hate with one another.
And Jews do not like Christians. With good reason. It was, after all, Christian values and morals and Christian cultures and societies that got them kicked out of every nation that has played host to them for the last two thousand years.
Just to give two examples, in John 8: 39-45, Christ says that Jews are not the children of Abraham, but of the devil, and that they do their father’s work on this earth. And in Matthew 15:1-9, Christ attacks the Pharisees for placing their own Oral Law above the laws given to them by God. And as anyone who knows anything about Jewish culture could tell you, spitting on the Oral Law and arguing that they turned their backs on God by worshiping the teachings of Rabbis and the words of men instead is about as direct an attack on Jewishness as you can muster.
Christianity is not merely Anti-Semitic, it is actually Counter-Semitic. In fact, the Talmud explicitly forbids any Orthodox Jew from reading so much as a single sentence from the Bible, and warns that if they do, they will be denied any place or reward in the coming age. This blatant censorship on the part of the Rabbis of the second and third century AD is indicative of how terrified the Jews were of Christianity, because lest we forget, the overwhelming number of original Christians were, obviously, Jews themselves who abandoned Jewishness to follow the teachings of Christ instead.
This was the single most direct threat on the existence of Judaism that the Jews have ever suffered, because it threatened to destroy them by the one thing they had thought themselves immune to: assimilation. For centuries, Jews used assimilation as a weapon against their foes and as a survival strategy to endure the attacks of their enemies. Indeed, the entire reason the Jews track blood by the female line instead of the male one is that it allows the Jews as a tribe to destroy rival groups by giving their daughters over to be married. You think you have won, and take your rightful spoils, but come to find out, your beloved son or grandson is actually first a Jew, and second whatever it is you were. Thus did the Jews of the Ancient Era destroy their enemies and rivals, by using their own women as a sort of tribal bioweapon to culturally and ethnically appropriate their enemies. They were the undisputed masters of assimilation.
But with the advent of Christianity, the tables had been turned. The diaspora was hemorrhaging members as Jews willingly turned their backs on their own Jewishness, and something had to be done to stop it, or else Judaism would go extinct, swallowed whole by Christianity.
Judaism survived, thanks to the efforts of the Rabbis to censor biblical teachings and centralize Jewish law for those Jews that followed them. Out of the dozens of different traditions and tribes of what had been considered the people of Israel, only one, the Rabbinical one which became hyper-insular, survived the rise of Christendom without being converted or swallowed up.
And Judaism, by which I mean the Rabbis who created what we refer to today as Jews and Jewishness, never forgot it. They never, ever forgot what Christianity did to it, or how close they came to being wiped out ideologically. And they have never forgiven Christianity or Christians for ‘stealing’ what they believed to be their rightful place at the head of the world. Even now, Martin Schulz openly declares in European Parliament that Europe belongs to the Jews and would not be Europe without Jews, and British Rabbi Jonathan Sacks is arguing, in the face of rising tides of anti-Semitism, that Jews are Europe’s rightful leaders and that if Europe should reject Jews, they will be forever damned.

The Jew cries out in pain as he names himself
The Jewish condition has for two thousand years been defined by Loxism, or the envy and hatred of whites by Jews, and this envy and hatred is a very real and observable phenomena. Why don’t they like us?
Because we, the Anglo-Germanic children of the Holy Roman Empire, took the place in the sun they always wanted for themselves. Because while they dreamed themselves the Masters of the Earth, we became the Masters of the Earth. Because Christianity became what the Jews always wanted to be. And they will never, ever stop seeing us as Christians, any more than they would ever stop seeing themselves as Jews. To the Jew, Christianity will finally be vanquished when the last white infant on Earth is used as a football by the disgruntled brown hordes, and not one moment sooner.
I know Jews today who think the Jewish grudge against Germans is silly, and that it is long past due to bury the hatchet and let bygones be bygones. But if you so much as mention Christianity to them, they practically foam at the mouth with vitriol and hatred. Jews would forgive Nazis before they forgive Christians, and the idea of Judeo-Christianity is without a doubt a swindle for the ages. They work hard to keep the hatred hidden from the sight of the uninitiated, but it is always there, bubbling just beneath the surface, and it only needs to be poked and prodded lightly to spill forth into the light of day.
Jews are a people who still, to this day, refuse to use a + sign in mathematics because it looks too much like a cross. The very reason we call them ‘kikes’ at all is because, on Ellis Island, immigrants from the Old World who were illiterate could sign their immigration papers with an X instead of their name if they needed to, but the Jews coming to America refused to draw anything that looked like a cross or crucifix, forcing an exception to be made. We allowed them to sign their names with a circle instead, and the Yiddish word for circle? Kikel. The nickname for Jews who hate Christ so much they’ll sign their names with a circle has dogged them ever since.
The flat-out refusal to even draw something resembling a cross in our postmodern enlightened world of irreverence and post-ironic flippancy is something that beggars the minds of most. It is sincerely difficult to imagine a hatred of the magnitude that Jews harbor for Christians, and I have little doubt that the majority of the New Testament teachings about showing love to your enemies were aimed directly at Jews. By all accounts, being told to love by a man they hated only enraged the Pharisees further.
As much as I dislike the vibrancy and multiculturalism I am forced to live around, my own hatred seems like little more than a mild distaste when compared to that which the Jew harbors. After all, although it is not the best outcome imaginable, I myself would be perfectly content for all of these people to simply be removed back to their nations of origin, never to darken my shores or the shores of any white land again. But the Jew is consumed by what can only be described as an adolescent revenge fantasy over two thousand years in the making, and many of them have little compunction on acting out their fantasies with great relish.
What does this have to do with claiming the Alt-Right is exclusively for Christians, you ask?
Simply put, they hate the Alt-Right and what it represents, and there could be no greater slur a Jew could use in their own terms than to call something “Christian.”
When Ethan Jacobs called the Alt-Right a Christian movement, he was using Christian as an insult, a smear, a signal to his fellow Chosenbergs and the shabbos goyim who follow a rag like Inverse about how evil and foul the Alt-Right really is.
They’re Christian over there, Moshi, can you believe it!? What awful people! We’re gonna have to do something about that.
Rejoice, tree huggers and fedoralords. You are all Christian now.
We have forgotten that we are all Christian. We have forgotten that we are the Forest People. We have forgotten the Virtue of Hate, and that being God Fearing means to be wrathful in the face of wickedness.
We have allowed our culture, our morals, our ethics, our society, and even our blood to be scrubbed away from us, leaving our identity as a blank slate. We were talked out of believing in our own diaspora, and yet allowed our enemies to keep theirs. All we have left is our Magic Dirt, and now the brown hordes, predictably, demand we turn over that as well.
It is only natural, it simply stands to reason, that after what has been done to us we would have to relearn these things and rediscover who we are, who we have been all along.
We will have a bulwark against subversion when we understand the truth that the Jews see in us, and embrace explicit Cultural Christendom instead of simply allowing it to be implicit in the form of Conservative Libertarianism or esoteric Socialist Nationalism. When atheists and pagans defend Christian society and Christian values, the Jews can’t win, and they know it.

Monday, January 7, 2019

Larotrectinib - New Cancer Drug

Lilly makes $8 billion bet on drugs for rare cancers with Loxo Oncology buy

FILE PHOTO: An orchid stands on a table at the entrance to Loxo Oncology headquarters in Stamford, Connecticut, U.S., February 20, 2018. Picture taken February 20, 2018. REUTERS/Bill Berkrot
By Tamara Mathias and Ankur Banerjee
(Reuters) - Eli Lilly said on Monday it will buy Loxo Oncology Inc for $8 billion, an expensive bet on a pipeline of cancer drugs that target rare genetic mutations and the biggest acquisition in the drugmaker's 143-year history.
The price represents a 68 percent premium to Loxo's Friday share price close, which some Wall Street analysts said was high for a company with only one drug on the market that it shares with a partner.
Loxo shares surged 66 percent to $232.65, close to the offer price of $235 per share, and prompted stock price rises for a other small developers of targeted cancer therapies, including Array BioPharma, Blueprint Medicines Corp and Clovis Oncology Inc. Lilly shares rose 0.5 percent to $115.28.
The cash deal comes on the heels of Bristol-Myers Squibb Co's agreement last week to buy Celgene Corp for $74 billion in the largest pharmaceutical deal ever, spurring investors' hopes of a new wave of large healthcare acquisitions.
Loxo gained prominence in 2017 - just three years after going public - with impressive clinical trial results showing its drug to be highly effective on cancers driven by a single gene mutation known as TRK fusion, regardless of where in the body the tumors originated.
These patients, with more than 17 different types of advanced cancer but all with the same genetic mutation, had run out of other treatment options. Yet some 80 percent who received Loxo's first drug, a pill called larotrectinib, experienced dramatic, often long-term improvement.
The Connecticut-based company won U.S. approval in November for the treatment under the brand name Vitrakvi, which is sold in partnership with Bayer AG. Lilly said it "very much" wants to continue the agreement with Bayer, which sells Vitrakvi outside the United States and shares U.S. commercial costs and profits with Loxo.
Loxo is also developing LOXO-292 targeting a different rare gene mutation, and analysts have forecast eventual annual sales of over $1 billion. Lilly would gain full control of that drug as it is not part of Loxo's Bayer collaboration.
In an interview, Lilly Chief Executive David Ricks said that drug targeting a mutation known as RET, seen in thyroid, lung and other cancers, was a major driver of the deal. It received breakthrough therapy designation from U.S. regulators, which could speed its path to approval.
Loxo was quick to take advantage of new technologies that can isolate genetic drivers of tumor growth, and the willingness of regulators to approve treatments across tumor types when a specific defect is present, Ricks said at the annual JPMorgan Healthcare Conference in San Francisco on Monday.
"Loxo sort of predicted that and then capitalized on that in a way that created value," Ricks said, adding that the acquisition will help Lilly identify new targetable mutations. He said Lilly was also interested in expanding in immuno-oncology through its own research and possible deals.

Targeted therapies offer the promise of potentially dramatic results if patients most likely to benefit are correctly identified, and are seen as a potential alternative to chemotherapy and its many adverse side effects.
"The acquisition of Loxo, along with last week's acquisition of Celgene, may represent the cream of the crop in biotech being harvested by big pharma," IFS Securities analyst David Bouchey said. "The size of the deal may indicate Lilly's willingness to pay up to out-bid the competition."
BMO Capital Markets analyst Alex Arfaei said the $8 billion valuation seemed high as Wall Street does not expect Loxo revenue to reach $1 billion until 2023.
Loxo's drugs present the particular challenge of finding advanced cancer patients with the rare genetic mutations, which will require significantly increased use of advanced sequencing of tumors. The TRK mutation targeted by Vitrakvi only occurs in about 1 percent of patients with solid tumor cancers.
That effort got a boost last year, when the U.S. government said its Medicare program will cover so-called next generation sequencing, which looks for hundreds of mutations across all solid tumors, for advanced cancer patients.
Lilly has typically eschewed large deals, preferring to develop its own drugs. But last year it paid $1.6 billion for Armo Biosciences, a developer of immunotherapy cancer drugs, and said in November it was open to more deals.
Lilly's oncology portfolio includes lung cancer chemotherapy Alimta, which had third-quarter sales of $520.5 million.
Vitrakvi, priced at $32,800 per month, and experimental follow-up drug LOXO-195, on which Bayer is also a partner, together could generate annual sales of about $750 million, according to Piper Jaffray & Co.
Bayer said it does not expect the Lilly deal to impact its contract with Loxo for the time being.
Loxo's shares have run up nearly 65 percent over the past 12 months, and ten-fold since its IPO in 2014, while Lilly's stock has surged about 35 percent since last January.
(Reporting by Ankur Banerjee and Tamara Mathias in Bengaluru; Additional reporting by Deena Beasley in San Francisco; Editing by Sweta Singh and Bill Berkrot)